Disease Research
疾病特異性、高純度的ECT-人源病齡病理亞型神經(jīng)細(xì)胞，可以快速建庫(kù)、凍存復(fù)蘇、長(zhǎng)期培養(yǎng)，適用于各種年齡、各種樣本規(guī)模的病理機(jī)制研究
寧波易賽騰生物科技有限公司獨(dú)立研發(fā)的ECT快速直接轉(zhuǎn)分化技術(shù)，打破了iPSC技術(shù)步驟繁瑣、周期冗長(zhǎng)、細(xì)胞胚齡化、無(wú)關(guān)鍵病理特征的主要局限。本公司特有的ECT技術(shù)快速制備的各種高純度亞神經(jīng)細(xì)胞（ECT-N）系列商業(yè)化產(chǎn)品，突破了相關(guān)藥物研發(fā)領(lǐng)域無(wú)人源性年齡匹配、病理特征匹配的細(xì)胞模型的瓶頸，是神經(jīng)退行性疾病機(jī)制研究及細(xì)胞篩藥的理想模型。
2. Mertens, J. et al. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell 28, 1533-1548 e1536, (2021).
3. Mertens, J. et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell 17, (2015).
4. Liu, M. L., Zang, T. & Zhang, C. L. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep 14, 115-128, (2016).
5. Victor, M. B. et al. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci 21, 341-352, (2018).
6. Tang, Y., Liu, M. L., Zang, T. & Zhang, C. L. Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons. Front Mol Neurosci 10, 359, (2017).
